G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

[Image: see text] Synthetic lethality is a genetic concept in which cell death is induced by the combination of mutations in two sensitive genes, while mutation of either gene alone is not sufficient to affect cell survival. Synthetic lethality can also be achieved “chemically” by combination of dru...

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Detalles Bibliográficos
Autores principales: McLuckie, Keith I. E., Di Antonio, Marco, Zecchini, Heather, Xian, Jian, Caldas, Carlos, Krippendorff, Ben-Fillippo, Tannahill, David, Lowe, Christopher, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964824/
https://www.ncbi.nlm.nih.gov/pubmed/23782415
http://dx.doi.org/10.1021/ja404868t

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