Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point

The mouse immunoglobulin (IgM) pre-mRNA contains a splicing inhibitor that bears multiple binding sites for the splicing repressor polypyrimidine tract binding protein (PTB). Here we show that the inhibitor directs assembly of an ATP-dependent complex that contains PTB and U1 and U2 small nuclear RN...

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Detalles Bibliográficos
Autores principales: Zheng, Xuexiu, Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Huyn Kyung, Green, Michael R., Shen, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964906/
https://www.ncbi.nlm.nih.gov/pubmed/24572809
http://dx.doi.org/10.1261/rna.043737.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964906/
https://www.ncbi.nlm.nih.gov/pubmed/24572809
http://dx.doi.org/10.1261/rna.043737.113

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