An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates

RNA aptamers are being developed as inhibitors of macromolecular and cellular function, diagnostic tools, and potential therapeutics. Our understanding of the physical nature of this emerging class of nucleic acid–protein complexes is limited; few atomic resolution structures have been reported for...

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Detalles Bibliográficos
Autores principales: Padlan, Camille S., Malashkevich, Vladimir N., Almo, Steve C., Levy, Matthew, Brenowitz, Michael, Girvin, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964907/
https://www.ncbi.nlm.nih.gov/pubmed/24570482
http://dx.doi.org/10.1261/rna.043034.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964907/
https://www.ncbi.nlm.nih.gov/pubmed/24570482
http://dx.doi.org/10.1261/rna.043034.113

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