Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development

In recent years, it has become clear that splicing factors play a direct role in cancer development. We showed previously that splicing factors SRSF1, SRSF6, and hnRNP A2/B1 are up-regulated in several cancers and can act as oncogenes when up-regulated. Here we examined the role of splicing factors...

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Detalles Bibliográficos
Autores principales: Shilo, Asaf, Ben Hur, Vered, Denichenko, Polina, Stein, Ilan, Pikarsky, Eli, Rauch, Jens, Kolch, Walter, Zender, Lars, Karni, Rotem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964912/
https://www.ncbi.nlm.nih.gov/pubmed/24572810
http://dx.doi.org/10.1261/rna.042259.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964912/
https://www.ncbi.nlm.nih.gov/pubmed/24572810
http://dx.doi.org/10.1261/rna.042259.113

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