The Orally Available, Synthetic Ether Lipid Edelfosine Inhibits T Cell Proliferation and Induces a Type I Interferon Response

The drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It acts on cellular membranes by selectively aggregating the cell death receptor Fas in membrane rafts and interference with phosphatidylchol...

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Detalles Bibliográficos
Autores principales: Abramowski, Pierre, Otto, Benjamin, Martin, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965404/
https://www.ncbi.nlm.nih.gov/pubmed/24667731
http://dx.doi.org/10.1371/journal.pone.0091970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965404/
https://www.ncbi.nlm.nih.gov/pubmed/24667731
http://dx.doi.org/10.1371/journal.pone.0091970

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