Toxicity and Biodistribution of the Serotype 2 Recombinant Adeno-Associated Viral Vector, Encoding Aquaporin-1, after Retroductal Delivery to a Single Mouse Parotid Gland

In preparation for testing the safety of using serotype 2 recombinant adeno-associated vector, encoding Aquaporin-1 to treat radiation-induced salivary gland damage in a phase 1 clinical trial, we conducted a 13 week GLP biodistribution and toxicology study using Balb/c mice. To best assess the safe...

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Detalles Bibliográficos
Autores principales: Momot, Dariya, Zheng, Changyu, Yin, Hongen, Elbekai, Reem H., Vallant, Molly, Chiorini, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965469/
https://www.ncbi.nlm.nih.gov/pubmed/24667436
http://dx.doi.org/10.1371/journal.pone.0092832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965469/
https://www.ncbi.nlm.nih.gov/pubmed/24667436
http://dx.doi.org/10.1371/journal.pone.0092832

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