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Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling
Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemore...
Autores principales: | Ferreira de Oliveira, José Miguel P., Costa, Maria, Pedrosa, Tiago, Pinto, Pedro, Remédios, Catarina, Oliveira, Helena, Pimentel, Francisco, Almeida, Luís, Santos, Conceição |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965485/ https://www.ncbi.nlm.nih.gov/pubmed/24667842 http://dx.doi.org/10.1371/journal.pone.0092980 |
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