A Transgenic Platform for Testing Drugs Intended for Reversal of Cardiac Remodeling Identifies a Novel 11βHSD1 Inhibitor Rescuing Hypertrophy Independently of Re-Vascularization

RATIONALE: Rescuing adverse myocardial remodeling is an unmet clinical goal and, correspondingly, pharmacological means for its intended reversal are urgently needed. OBJECTIVES: To harness a newly-developed experimental model recapitulating progressive heart failure development for the discovery of...

Descripción completa

Detalles Bibliográficos
Autores principales: Gordon, Oren, He, Zhiheng, Gilon, Dan, Gruener, Sabine, Pietranico-Cole, Sherrie, Oppenheim, Amit, Keshet, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965501/
https://www.ncbi.nlm.nih.gov/pubmed/24667808
http://dx.doi.org/10.1371/journal.pone.0092869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965501/
https://www.ncbi.nlm.nih.gov/pubmed/24667808
http://dx.doi.org/10.1371/journal.pone.0092869

Ejemplares similares