EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. We previously found that nuclear accumulation of histone deacetylase-4, HDAC4, contributes to this degeneration; we now report that increased histone H3K27 trimethylation (H3K27me3)...

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Detalles Bibliográficos
Autores principales: Li, Jiali, Hart, Ronald P., Mallimo, Elyse M., Swerdel, Mavis R., Kusnecov, Alexander, Herrup, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965909/
https://www.ncbi.nlm.nih.gov/pubmed/24162653
http://dx.doi.org/10.1038/nn.3564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965909/
https://www.ncbi.nlm.nih.gov/pubmed/24162653
http://dx.doi.org/10.1038/nn.3564

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