Discovery of new enzymes and metabolic pathways using structure and genome context

Assigning valid functions to proteins identified in genome projects is challenging, with over-prediction and database annotation errors major concerns(1). We, and others(2), are developing computation-guided strategies for functional discovery using “metabolite docking” to experimentally derived(3)...

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Detalles Bibliográficos
Autores principales: Zhao, Suwen, Kumar, Ritesh, Sakai, Ayano, Vetting, Matthew W., Wood, B. McKay, Brown, Shoshana, Bonanno, Jeffery B., Hillerich, Brandan S., Seidel, Ronald D., Babbitt, Patricia C., Almo, Steven C., Sweedler, Jonathan V., Gerlt, John A., Cronan, John E., Jacobson, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966649/
https://www.ncbi.nlm.nih.gov/pubmed/24056934
http://dx.doi.org/10.1038/nature12576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966649/
https://www.ncbi.nlm.nih.gov/pubmed/24056934
http://dx.doi.org/10.1038/nature12576

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