Cargando…

Impact of intracellular domain flexibility upon properties of activated human 5-HT(3) receptors*

BACKGROUND AND PURPOSE: It has been proposed that arginine residues lining the intracellular portals of the homomeric 5-HT(3)A receptor cause electrostatic repulsion of cation flow, accounting for a single-channel conductance substantially lower than that of the 5-HT(3)AB heteromer. However, compari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kozuska, J L, Paulsen, I M, Belfield, W J, Martin, I L, Cole, D J, Holt, A, Dunn, S M J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons Ltd 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966743/ https://www.ncbi.nlm.nih.gov/pubmed/24283776 http://dx.doi.org/10.1111/bph.12536

Ejemplares similares

Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT(3A) receptors
por: Pandhare, Akash, et al.
Publicado: (2019)

Mutagenic Analysis of the Intracellular Portals of the Human 5-HT(3)A Receptor
por: Carland, Jane E., et al.
Publicado: (2013)

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor
por: Bondarenko, Vasyl, et al.
Publicado: (2022)

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, Andrew J., et al.
Publicado: (2014)

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT(2A )or 5-HT(2C )receptors
por: Seitz, Patricia K, et al.
Publicado: (2012)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
por: Spencer, Nick J.
Publicado: (2015)

5-HT(7) receptor signaling: improved therapeutic strategy in gut disorders
por: Kim, Janice J., et al.
Publicado: (2014)

Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi
por: Hall, Brian, et al.
Publicado: (2012)

Tumourigenic multidrug-resistant HT1080 cells do not overexpress receptors for epidermal growth factor.
por: Slovak, M. L., et al.
Publicado: (1991)

Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT(1A) Receptor Ligands
por: Walory, Jarosław, et al.
Publicado: (2018)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

The role of 5-HT receptors in depression
por: Yohn, Christine N., et al.
Publicado: (2017)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT(3) and 5-HT(6) Receptor Antagonist with Antipsychotic and Procognitive Properties
por: Zajdel, Paweł, et al.
Publicado: (2021)

Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT(2) and 5-HT(1) Receptors
por: van Wel, Janelle H. P., et al.
Publicado: (2012)

Therapeutic Potential of 5-HT(2C) Receptor Ligands
por: Jensen, Nanna H., et al.
Publicado: (2010)

5-HT(2A) and 5-HT(2C) receptors as hypothalamic targets of developmental programming in male rats
por: Martin-Gronert, Malgorzata S., et al.
Publicado: (2016)

The 5-HT(2C) receptor agonist, lorcaserin, and the 5-HT(6) receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
por: Higgs, Suzanne, et al.
Publicado: (2015)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

A single channel mutation alters agonist efficacy at 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, A J, et al.
Publicado: (2013)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Translating the promise of 5HT(4) receptor agonists for the treatment of depression
por: Murphy, Susannah E, et al.
Publicado: (2021)

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT(3)A and 5-HT(3)AB receptors()
por: Lummis, Sarah C.R., et al.
Publicado: (2013)

5-HT Receptors and Temperature Homeostasis
por: Voronova, Irina P.
Publicado: (2021)

Structure–Activity Relationships of Quinoxaline-Based 5-HT(3)A and 5-HT(3)AB Receptor-Selective Ligands
por: Thompson, Andrew J, et al.
Publicado: (2013)

Identification of 5-HT(2A) Receptor Signaling Pathways Responsible for Psychedelic Potential
por: Wallach, Jason, et al.
Publicado: (2023)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

High-affinity fluorescent ligands for the 5-HT(3) receptor
por: Simonin, Jonathan, et al.
Publicado: (2012)

5-HT6 receptor agonism facilitates emotional learning
por: Pereira, Marcela, et al.
Publicado: (2015)

Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord
por: Perrin, F E, et al.
Publicado: (2011)

Identification of a Domain which Affects Kinetics and Antagonistic Potency of Clozapine at 5-HT(3) Receptors
por: Rammes, Gerhard, et al.
Publicado: (2009)

Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity
por: Kurczab, Rafał, et al.
Publicado: (2016)

Association Between 5HT1b Receptor Gene and Methamphetamine Dependence
por: Ujike, H, et al.
Publicado: (2011)

Structural basis of ligand recognition in 5-HT(3) receptors
por: Kesters, Divya, et al.
Publicado: (2013)

Loop B Is a Major Structural Component of the 5-HT(3) Receptor
por: Thompson, A. J., et al.
Publicado: (2008)

MDMA-induced indifference to negative sounds is mediated by the 5-HT(2A) receptor
por: Kuypers, K. P. C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j38hantflvdnkjc7k02ktplpvh