In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract

BACKGROUND AND PURPOSE: GNF-351 is a potent aryl hydrocarbon receptor (AHR) antagonist that inhibits dioxin response element-dependent and independent activities. Here, the absorption, metabolism and in vivo AHR antagonist activity of GNF-351 were investigated. EXPERIMENTAL APPROACH: LC-MS metabolom...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Zhong-Ze, Krausz, Kristopher W, Nagaoka, Kenjiro, Tanaka, Naoki, Gowda, Krishne, Amin, Shantu G, Perdew, Gary H, Gonzalez, Frank J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966752/
https://www.ncbi.nlm.nih.gov/pubmed/24417285
http://dx.doi.org/10.1111/bph.12576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966752/
https://www.ncbi.nlm.nih.gov/pubmed/24417285
http://dx.doi.org/10.1111/bph.12576

Ejemplares similares