Comparisons of Native Shiga Toxins (Stxs) Type 1 and 2 with Chimeric Toxins Indicate that the Source of the Binding Subunit Dictates Degree of Toxicity

Shiga toxin (Stx)-producing E. coli (STEC) cause food-borne outbreaks of hemorrhagic colitis. The main virulence factor expressed by STEC, Stx, is an AB(5) toxin that has two antigenically distinct forms, Stx1a and Stx2a. Although Stx1a and Stx2a bind to the same receptor, globotriaosylceramide (Gb3...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Lisa M., Melton-Celsa, Angela R., Smith, Michael J., O'Brien, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966898/
https://www.ncbi.nlm.nih.gov/pubmed/24671194
http://dx.doi.org/10.1371/journal.pone.0093463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966898/
https://www.ncbi.nlm.nih.gov/pubmed/24671194
http://dx.doi.org/10.1371/journal.pone.0093463

Ejemplares similares