The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated antioxidant defense pathway is a critical step in the pathogenesis of several chronic pulmonary diseases and cancer. While the mechanism of NRF2 activation upon oxidative stress has been widely investigated,...

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Detalles Bibliográficos
Autores principales: Pekovic-Vaughan, Vanja, Gibbs, Julie, Yoshitane, Hikari, Yang, Nan, Pathiranage, Dharshika, Guo, Baoqiang, Sagami, Aya, Taguchi, Keiko, Bechtold, David, Loudon, Andrew, Yamamoto, Masayuki, Chan, Jefferson, van der Horst, Gijsbertus T.J., Fukada, Yoshitaka, Meng, Qing-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967045/
https://www.ncbi.nlm.nih.gov/pubmed/24637114
http://dx.doi.org/10.1101/gad.237081.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967045/
https://www.ncbi.nlm.nih.gov/pubmed/24637114
http://dx.doi.org/10.1101/gad.237081.113

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