The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated antioxidant defense pathway is a critical step in the pathogenesis of several chronic pulmonary diseases and cancer. While the mechanism of NRF2 activation upon oxidative stress has been widely investigated,...

Descripción completa

Detalles Bibliográficos
Autores principales: Pekovic-Vaughan, Vanja, Gibbs, Julie, Yoshitane, Hikari, Yang, Nan, Pathiranage, Dharshika, Guo, Baoqiang, Sagami, Aya, Taguchi, Keiko, Bechtold, David, Loudon, Andrew, Yamamoto, Masayuki, Chan, Jefferson, van der Horst, Gijsbertus T.J., Fukada, Yoshitaka, Meng, Qing-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967045/
https://www.ncbi.nlm.nih.gov/pubmed/24637114
http://dx.doi.org/10.1101/gad.237081.113

Ejemplares similares

Ejemplares similares