Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

Glutamine (Gln) metabolism, initiated by its degradation by glutaminases (GA), is elevated in neoplastic cells and tissues. In malignant glia-derived tumors, GA isoforms, KGA and GAC, coded by the GLS gene, are overexpressed, whereas the GLS2-coded GAB and LGA isoforms, are hardly detectable in ther...

Descripción completa

Detalles Bibliográficos
Autores principales: Szeliga, Monika, Bogacińska-Karaś, Małgorzata, Różycka, Aleksandra, Hilgier, Wojciech, Marquez, Javier, Albrecht, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967065/
https://www.ncbi.nlm.nih.gov/pubmed/24096582
http://dx.doi.org/10.1007/s13277-013-1247-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967065/
https://www.ncbi.nlm.nih.gov/pubmed/24096582
http://dx.doi.org/10.1007/s13277-013-1247-4

Ejemplares similares