Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can be received and interpreted by mTORC2 and further transduced to mTORC1. On the...

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Detalles Bibliográficos
Autores principales: Liu, Pengda, Guo, Jianping, Gan, Wenjian, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967077/
https://www.ncbi.nlm.nih.gov/pubmed/24481632
http://dx.doi.org/10.1007/s13238-014-0021-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967077/
https://www.ncbi.nlm.nih.gov/pubmed/24481632
http://dx.doi.org/10.1007/s13238-014-0021-8

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