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Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can be received and interpreted by mTORC2 and further transduced to mTORC1. On the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Higher Education Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967077/ https://www.ncbi.nlm.nih.gov/pubmed/24481632 http://dx.doi.org/10.1007/s13238-014-0021-8 |