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Pediatric Dosing and Body Size in Biotherapeutics

Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m(2)), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (...

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Detalles Bibliográficos
Autores principales: Shi, Rong, Derendorf, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967145/
https://www.ncbi.nlm.nih.gov/pubmed/27721364
http://dx.doi.org/10.3390/pharmaceutics2040389