The Influence of Milling on the Dissolution Performance of Simvastatin

Particle size reduction is a simple means to enhance the dissolution rate of poorly water soluble BCS-class II and IV drugs. However, the major drawback of this process is the possible introduction of process induced disorder. Drugs with different molecular arrangements may exhibit altered propertie...

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Detalles Bibliográficos
Autores principales: Zimper, Ulrike, Aaltonen, Jaakko, Krauel-Goellner, Karen, Gordon, Keith C., Strachan, Clare J., Rades, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967146/
https://www.ncbi.nlm.nih.gov/pubmed/27721365
http://dx.doi.org/10.3390/pharmaceutics2040419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967146/
https://www.ncbi.nlm.nih.gov/pubmed/27721365
http://dx.doi.org/10.3390/pharmaceutics2040419

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