Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-x(L) Binding to Bim

A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Chunwei, Liu, Yan, Balasis, Maria E., Simmons, Nicholas L., Li, Jerry, Song, Hao, Pan, Lili, Qin, Yong, Nicolaou, K. C., Sebti, Said M., Li, Rongshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967213/
https://www.ncbi.nlm.nih.gov/pubmed/24608970
http://dx.doi.org/10.3390/md12031335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967213/
https://www.ncbi.nlm.nih.gov/pubmed/24608970
http://dx.doi.org/10.3390/md12031335

Ejemplares similares