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Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-x(L) Binding to Bim

A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabr...

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Detalles Bibliográficos
Autores principales:	Cheng, Chunwei, Liu, Yan, Balasis, Maria E., Simmons, Nicholas L., Li, Jerry, Song, Hao, Pan, Lili, Qin, Yong, Nicolaou, K. C., Sebti, Said M., Li, Rongshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967213/ https://www.ncbi.nlm.nih.gov/pubmed/24608970 http://dx.doi.org/10.3390/md12031335

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