Largazole Pharmacokinetics in Rats by LC-MS/MS

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma alo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Mingming, Salvador, Lilibeth A., Sy, Sherwin K. B., Tang, Yufei, Singh, Ravi S. P., Chen, Qi-Yin, Liu, Yanxia, Hong, Jiyong, Derendorf, Hartmut, Luesch, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967229/
https://www.ncbi.nlm.nih.gov/pubmed/24658499
http://dx.doi.org/10.3390/md12031623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967229/
https://www.ncbi.nlm.nih.gov/pubmed/24658499
http://dx.doi.org/10.3390/md12031623

Ejemplares similares