Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

Reverse rate dependence is a problematic property of antiarrhythmic drugs that prolong the cardiac action potential (AP). The prolongation caused by reverse rate dependent agents is greater at slow heart rates, resulting in both reduced arrhythmia suppression at fast rates and increased arrhythmia r...

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Detalles Bibliográficos
Autores principales: Cummins, Megan A., Dalal, Pavan J., Bugana, Marco, Severi, Stefano, Sobie, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967944/
https://www.ncbi.nlm.nih.gov/pubmed/24675446
http://dx.doi.org/10.1371/journal.pcbi.1003543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967944/
https://www.ncbi.nlm.nih.gov/pubmed/24675446
http://dx.doi.org/10.1371/journal.pcbi.1003543

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