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Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

A functional unfolded protein response (UPR) is essential for endoplasmic reticulum (ER)-associated degradation (ERAD) of misfolded secretory proteins, reflecting the fact that some level of UPR activation must exist under normal physiological conditions. A coordinator of the UPR and ERAD processes...

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Detalles Bibliográficos
Autores principales: Leitman, Julia, Shenkman, Marina, Gofman, Yana, Shtern, Navit Ogen, Ben-Tal, Nir, Hendershot, Linda M., Lederkremer, Gerardo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967970/
https://www.ncbi.nlm.nih.gov/pubmed/24478453
http://dx.doi.org/10.1091/mbc.E13-06-0350