Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1

As early endosomes mature, the SAND-1/CCZ-1 complex acts as a guanine nucleotide exchange factor (GEF) for RAB-7 to promote the activity of its effector, HOPS, which facilitates late endosome–lysosome fusion and the consumption of AP-3–containing vesicles. We show that CCZ-1 and the HOPS complex are...

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Detalles Bibliográficos
Autores principales: Delahaye, Jared L., Foster, Olivia K., Vine, Annalise, Saxton, Daniel S., Curtin, Thomas P., Somhegyi, Hannah, Salesky, Rebecca, Hermann, Greg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967972/
https://www.ncbi.nlm.nih.gov/pubmed/24501423
http://dx.doi.org/10.1091/mbc.E13-09-0521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967972/
https://www.ncbi.nlm.nih.gov/pubmed/24501423
http://dx.doi.org/10.1091/mbc.E13-09-0521

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