Cargando…

ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brown, Adam D., Sager, Brian W., Gorthi, Aparna, Tonapi, Sonal S., Brown, Eric J., Bishop, Alexander J. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968013/ https://www.ncbi.nlm.nih.gov/pubmed/24675793 http://dx.doi.org/10.1371/journal.pone.0091222

Ejemplares similares

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair
por: Lima, Michelle, et al.
Publicado: (2016)

Ewing sarcoma fusion oncogene: At the crossroads of transcription and DNA damage response
por: Gorthi, Aparna, et al.
Publicado: (2018)

ATR is required to complete meiotic recombination in mice
por: Pacheco, Sarai, et al.
Publicado: (2018)

A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination
por: Dubois, Jean-Christophe, et al.
Publicado: (2017)

ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines
por: Wikiniyadhanee, Rakkreat, et al.
Publicado: (2023)

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair
por: Serrano, Moises A., et al.
Publicado: (2012)

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
por: Joyce, Eric F., et al.
Publicado: (2011)

Beta human papillomavirus 8 E6 allows colocalization of non-homologous end joining and homologous recombination repair factors
por: Hu, Changkun, et al.
Publicado: (2022)

BRCA2 Promotes Spontaneous Homologous Recombination In Vivo
por: Brown, Adam D., et al.
Publicado: (2021)

RAD18 transmits DNA damage signaling to elicit homologous recombination repair
por: Huang, Jun, et al.
Publicado: (2009)

ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells
por: Sirbu, Bianca M., et al.
Publicado: (2011)

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells
por: Kim, Dongsung, et al.
Publicado: (2018)

Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells
por: Xie, Lisha, et al.
Publicado: (2016)

Role of Homologous Recombination Genes in Repair of Alkylation Base Damage by Candida albicans
por: Ciudad, Toni, et al.
Publicado: (2018)

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
por: Liu, Lei, et al.
Publicado: (2021)

BRCA2 and homologous recombination
por: Orelli, Brian J, et al.
Publicado: (2001)

Involvement of Caveolin-1 in Repair of DNA Damage through Both Homologous Recombination and Non-Homologous End Joining
por: Zhu, Hua, et al.
Publicado: (2010)

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
por: Iwai, Kenichi, et al.
Publicado: (2021)

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
por: Ning, Jian-Fang, et al.
Publicado: (2019)

Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion
por: Brown, Adam D., et al.
Publicado: (2010)

The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA Repair
por: Pacheco-Barcia, Vilma, et al.
Publicado: (2022)

PARP1 suppresses homologous recombination events in mice in vivo
por: Claybon, Alison, et al.
Publicado: (2010)

Homologous Recombination and Its Role in Carcinogenesis
por: Bishop, Alexander J. R., et al.
Publicado: (2002)

Thé{circ}atre complet
por: Lenormand, H.-R. (Henri-René), 1882-1951
Publicado: (1921)

Thé{circ}atre complet /
por: Liègme, Bernard
Publicado: (1972)

Thé{circ}atre complet
por: Racine, Jean, 1639-1699
Publicado: (1960)

ATR inhibition reverses the resistance of homologous recombination deficient MGMT(low)/MMR(proficient) cancer cells to temozolomide
por: El Touny, Lara H., et al.
Publicado: (2021)

ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
por: Chen, Yuanyuan, et al.
Publicado: (2023)

Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair
por: Peng, Xin, et al.
Publicado: (2022)

Genetic polymorphisms in homologous recombination repair genes in healthy Slovenian population and their influence on DNA damage
por: Goricar, Katja, et al.
Publicado: (2012)

Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci
por: Vasianovich, Yulia, et al.
Publicado: (2017)

Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous Recombination
por: de Campos-Nebel, Marcelo, et al.
Publicado: (2010)

Homologous Recombination Repair Polymorphisms and the Risk for Osteosarcoma
por: Goričar, Katja, et al.
Publicado: (2015)

Leveraging homologous recombination repair deficiency in sarcoma
por: Slade, Dea, et al.
Publicado: (2023)

Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination
por: Zhai, Beibei, et al.
Publicado: (2018)

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
por: Randolph, Matthew E., et al.
Publicado: (2023)

PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer
por: Huang, Weicai, et al.
Publicado: (2022)

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
por: McNees, Carolyn J., et al.
Publicado: (2010)

The Importance of ATM and ATR in Physcomitrella patens DNA Damage Repair, Development, and Gene Targeting
por: Martens, Martin, et al.
Publicado: (2020)

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
por: Pereira, Catalina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ko2ag7m6aat1171466e863cnjn