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ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair
DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR)...
Autores principales: | Brown, Adam D., Sager, Brian W., Gorthi, Aparna, Tonapi, Sonal S., Brown, Eric J., Bishop, Alexander J. R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968013/ https://www.ncbi.nlm.nih.gov/pubmed/24675793 http://dx.doi.org/10.1371/journal.pone.0091222 |
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