Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

The Dyrk family of protein kinases is implicated in the pathogenesis of several diseases, including cancer and neurodegeneration. Pharmacological inhibitors were mainly described for Dyrk1A so far, but in fewer cases for Dyrk1B, Dyrk2 or other isoforms. Herein, we report the development and optimiza...

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Detalles Bibliográficos
Autores principales: Schmitt, Christian, Kail, Dagmar, Mariano, Marica, Empting, Martin, Weber, Nadja, Paul, Tamara, Hartmann, Rolf W., Engel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968014/
https://www.ncbi.nlm.nih.gov/pubmed/24676346
http://dx.doi.org/10.1371/journal.pone.0087851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968014/
https://www.ncbi.nlm.nih.gov/pubmed/24676346
http://dx.doi.org/10.1371/journal.pone.0087851

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