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Quantification of Process Induced Disorder in Milled Samples Using Different Analytical Techniques

The aim of this study was to compare three different analytical methods to detect and quantify the amount of crystalline disorder/ amorphousness in two milled model drugs. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman spectroscopy were used as analytical methods...

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Detalles Bibliográficos
Autores principales: Zimper, Ulrike, Aaltonen, Jaakko, McGoverin, Cushla M., Gordon, Keith C., Krauel-Goellner, Karen, Rades, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968347/
https://www.ncbi.nlm.nih.gov/pubmed/27721341
http://dx.doi.org/10.3390/pharmaceutics2010030