Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice

The transcription factor neurogenin3 (Ngn3) triggers islet cell differentiation in the developing pancreas. However, little is known about the molecular mechanisms coupling cell cycle exit and differentiation in Ngn3(+) islet progenitors. We identified a novel effector of Ngn3 endocrinogenic functio...

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Detalles Bibliográficos
Autores principales: Piccand, Julie, Meunier, Aline, Merle, Carole, Jia, Zhengping, Barnier, Jean-Vianney, Gradwohl, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968432/
https://www.ncbi.nlm.nih.gov/pubmed/24163148
http://dx.doi.org/10.2337/db13-0384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968432/
https://www.ncbi.nlm.nih.gov/pubmed/24163148
http://dx.doi.org/10.2337/db13-0384

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