Squaramide-Catalyzed Enantioselective Michael Addition of Masked Acyl Cyanides to Substituted Enones

[Image: see text] Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective Michael addition to substituted enones. The reactions are catalyzed by chiral squaramides and afford adducts in high yields (90–99%) and with excellent enantioselectivities (85–98%)....

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Detalles Bibliográficos
Autores principales: Yang, Kin S., Nibbs, Antoinette E., Türkmen, Yunus E., Rawal, Viresh H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968543/
https://www.ncbi.nlm.nih.gov/pubmed/24090310
http://dx.doi.org/10.1021/ja409012q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968543/
https://www.ncbi.nlm.nih.gov/pubmed/24090310
http://dx.doi.org/10.1021/ja409012q

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