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N-terminus oligomerization is conserved in intracellular calcium release channels

Oligomerization of all three mammalian ryanodine receptor isoforms, a structural requirement for normal intracellular Ca(2+) release channel function, is displayed by the discrete N-terminal domain which assembles into homo- and hetero-tetramers. This is demonstrated in yeast, mammalian cells and na...

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Detalles Bibliográficos
Autores principales: Zissimopoulos, Spyros, Marsh, Jason, Stannard, Laurence, Seidel, Monika, Lai, F. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969220/
https://www.ncbi.nlm.nih.gov/pubmed/24502647
http://dx.doi.org/10.1042/BJ20131061