In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions

P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from mammalian cells. P-gp plays a pivotal role in limiting drug absorption and distribution in different organs, including t...

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Detalles Bibliográficos
Autores principales: Shityakov, Sergey, Förster, Carola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969253/
https://www.ncbi.nlm.nih.gov/pubmed/24711707
http://dx.doi.org/10.2147/AABC.S56046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969253/
https://www.ncbi.nlm.nih.gov/pubmed/24711707
http://dx.doi.org/10.2147/AABC.S56046

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