Cargando…
In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions
P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from mammalian cells. P-gp plays a pivotal role in limiting drug absorption and distribution in different organs, including t...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969253/ https://www.ncbi.nlm.nih.gov/pubmed/24711707 http://dx.doi.org/10.2147/AABC.S56046 |