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Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

BACKGROUND: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases. OBJECTIVE: To investigate the neuroprotective effects of Cur to mitigate the effect...

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Autores principales: Sharma, Chhavi, Suhalka, Pooja, Sukhwal, Piyu, Jaiswal, Neha, Bhatnagar, Maheep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969660/
https://www.ncbi.nlm.nih.gov/pubmed/24696547
http://dx.doi.org/10.4103/0973-1296.126663
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author Sharma, Chhavi
Suhalka, Pooja
Sukhwal, Piyu
Jaiswal, Neha
Bhatnagar, Maheep
author_facet Sharma, Chhavi
Suhalka, Pooja
Sukhwal, Piyu
Jaiswal, Neha
Bhatnagar, Maheep
author_sort Sharma, Chhavi
collection PubMed
description BACKGROUND: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases. OBJECTIVE: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters. MATERIALS AND METHODS: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days. RESULT AND DISCUSSION: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in significant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone. CONCLUSION: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.
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spelling pubmed-39696602014-04-02 Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence Sharma, Chhavi Suhalka, Pooja Sukhwal, Piyu Jaiswal, Neha Bhatnagar, Maheep Pharmacogn Mag Original Article BACKGROUND: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases. OBJECTIVE: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters. MATERIALS AND METHODS: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days. RESULT AND DISCUSSION: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in significant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone. CONCLUSION: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3969660/ /pubmed/24696547 http://dx.doi.org/10.4103/0973-1296.126663 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sharma, Chhavi
Suhalka, Pooja
Sukhwal, Piyu
Jaiswal, Neha
Bhatnagar, Maheep
Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title_full Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title_fullStr Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title_full_unstemmed Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title_short Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence
title_sort curcumin attenuates neurotoxicity induced by fluoride: an in vivo evidence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969660/
https://www.ncbi.nlm.nih.gov/pubmed/24696547
http://dx.doi.org/10.4103/0973-1296.126663
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