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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Und...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970583/ https://www.ncbi.nlm.nih.gov/pubmed/24651012 http://dx.doi.org/10.1016/j.ccr.2014.01.021 |