Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Und...

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Detalles Bibliográficos
Autores principales: Muller, Patricia A.J., Vousden, Karen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970583/
https://www.ncbi.nlm.nih.gov/pubmed/24651012
http://dx.doi.org/10.1016/j.ccr.2014.01.021
Descripción
Sumario:Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

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