Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Und...

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Detalles Bibliográficos
Autores principales: Muller, Patricia A.J., Vousden, Karen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970583/
https://www.ncbi.nlm.nih.gov/pubmed/24651012
http://dx.doi.org/10.1016/j.ccr.2014.01.021
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author Muller, Patricia A.J.
Vousden, Karen H.
author_facet Muller, Patricia A.J.
Vousden, Karen H.
author_sort Muller, Patricia A.J.
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description Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
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spelling pubmed-39705832014-04-01 Mutant p53 in Cancer: New Functions and Therapeutic Opportunities Muller, Patricia A.J. Vousden, Karen H. Cancer Cell Perspective Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types. Cell Press 2014-03-17 /pmc/articles/PMC3970583/ /pubmed/24651012 http://dx.doi.org/10.1016/j.ccr.2014.01.021 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective
Muller, Patricia A.J.
Vousden, Karen H.
Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title_full Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title_fullStr Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title_full_unstemmed Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title_short Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
title_sort mutant p53 in cancer: new functions and therapeutic opportunities
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970583/
https://www.ncbi.nlm.nih.gov/pubmed/24651012
http://dx.doi.org/10.1016/j.ccr.2014.01.021
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