Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initi...

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Detalles Bibliográficos
Autores principales: Ratté, Stéphanie, Zhu, Yi, Lee, Kwan Yeop, Prescott, Steven A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970756/
https://www.ncbi.nlm.nih.gov/pubmed/24692450
http://dx.doi.org/10.7554/eLife.02370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970756/
https://www.ncbi.nlm.nih.gov/pubmed/24692450
http://dx.doi.org/10.7554/eLife.02370

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