Three-dimensional quantitative structure–activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors

The cytochrome P450 (CYP)3A4 enzyme affects the metabolism of most drug-like substances, and its inhibition may influence drug safety. Modulation of CYP3A4 by flavonoids, such as anthocyanins, has been shown to inhibit the mutagenic activity of mammalian cells. Considering the previous investigation...

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Detalles Bibliográficos
Autores principales: Shityakov, Sergey, Puskás, István, Roewer, Norbert, Förster, Carola, Broscheit, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970920/
https://www.ncbi.nlm.nih.gov/pubmed/24741320
http://dx.doi.org/10.2147/AABC.S56478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970920/
https://www.ncbi.nlm.nih.gov/pubmed/24741320
http://dx.doi.org/10.2147/AABC.S56478

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