Large Genomic Rearrangements of BRCA1 and BRCA2 among Patients Referred for Genetic Analysis in Galicia (NW Spain): Delimitation and Mechanism of Three Novel BRCA1 Rearrangements

In the Iberian Peninsula, which includes mainly Spain and Portugal, large genomic rearrangements (LGRs) of BRCA1 and BRCA2 have respectively been found in up to 2.33% and 8.4% of families with hereditary breast and/or ovarian cancer (HBOC) that lack point mutations and small indels. In Galicia (Nort...

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Detalles Bibliográficos
Autores principales: Fachal, Laura, Blanco, Ana, Santamariña, Marta, Carracedo, Angel, Vega, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970959/
https://www.ncbi.nlm.nih.gov/pubmed/24686251
http://dx.doi.org/10.1371/journal.pone.0093306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970959/
https://www.ncbi.nlm.nih.gov/pubmed/24686251
http://dx.doi.org/10.1371/journal.pone.0093306

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