An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

Poor prognosis oestrogen receptor positive breast cancer is characterized by the presence of high-level focal amplifications. We utilized a focused siRNA screen in 14 breast cancer cell lines to define genes that were pathogenic in three genomic regions focally amplified in oestrogen receptor positi...

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Detalles Bibliográficos
Autores principales: Garcia-Murillas, Isaac, Sharpe, Rachel, Pearson, Alex, Campbell, James, Natrajan, Rachael, Ashworth, Alan, Turner, Nicholas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970970/
https://www.ncbi.nlm.nih.gov/pubmed/23752180
http://dx.doi.org/10.1038/onc.2013.202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970970/
https://www.ncbi.nlm.nih.gov/pubmed/23752180
http://dx.doi.org/10.1038/onc.2013.202

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