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Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation
Characterizing novel drugs and chemical probes of biological systems is hindered by difficulties in identifying the mechanism of action (MOA) of biologically active molecules. Here we present a metabolite suppression approach to explore the MOA of antibacterial compounds under nutrient restriction....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970981/ https://www.ncbi.nlm.nih.gov/pubmed/24121552 http://dx.doi.org/10.1038/nchembio.1361 |