Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR–ABL1 fusion gene encoding for a chimeric BCR–ABL1 protein. It is present in 3–4% of pediatric acute lymphoblastic leukemia (Ph(+) ALL), and about 25% of adult ALL cases. Prior to the advent of tyrosine kinase inhibitors (TKI), Ph(+) ALL w...

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Detalles Bibliográficos
Autores principales: Bernt, Kathrin M., Hunger, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971203/
https://www.ncbi.nlm.nih.gov/pubmed/24724051
http://dx.doi.org/10.3389/fonc.2014.00054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971203/
https://www.ncbi.nlm.nih.gov/pubmed/24724051
http://dx.doi.org/10.3389/fonc.2014.00054

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