Incremental value of rare genetic variants for the prediction of multifactorial diseases

BACKGROUND: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. METHODS: In simulated data, we constructed risk models with a...

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Detalles Bibliográficos
Autores principales: Mihaescu, Raluca, Pencina, Michael J, Alonso, Alvaro, Lunetta, Kathryn L, Heckbert, Susan R, Benjamin, Emelia J, JW Janssens, A Cecile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971349/
https://www.ncbi.nlm.nih.gov/pubmed/23961719
http://dx.doi.org/10.1186/gm480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971349/
https://www.ncbi.nlm.nih.gov/pubmed/23961719
http://dx.doi.org/10.1186/gm480

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