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Incremental value of rare genetic variants for the prediction of multifactorial diseases
BACKGROUND: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. METHODS: In simulated data, we constructed risk models with a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971349/ https://www.ncbi.nlm.nih.gov/pubmed/23961719 http://dx.doi.org/10.1186/gm480 |