Differential Ca(v)2.1 and Ca(v)2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABA(B) receptor activation

Neuronal Ca(v)2.1 (P/Q-type), Ca(v)2.2 (N-type), and Ca(v)2.3 (R-type) calcium channels contribute to synaptic transmission and are modulated through G protein–coupled receptor pathways. The analgesic α-conotoxin Vc1.1 acts through γ-aminobutyric acid type B (GABA(B)) receptors (GABA(B)Rs) to inhibi...

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Detalles Bibliográficos
Autores principales: Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971658/
https://www.ncbi.nlm.nih.gov/pubmed/24688019
http://dx.doi.org/10.1085/jgp.201311104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971658/
https://www.ncbi.nlm.nih.gov/pubmed/24688019
http://dx.doi.org/10.1085/jgp.201311104

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