Stoichiometry of altered hERG1 channel gating by small molecule activators

Voltage-gated K(+) channels are tetramers formed by coassembly of four identical or highly related subunits. All four subunits contribute to formation of the selectivity filter, the narrowest region of the channel pore which determines K(+) selective conductance. In some K(+) channels, the selectivi...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Sachse, Frank B., Gardner, Alison, Sanguinetti, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971662/
https://www.ncbi.nlm.nih.gov/pubmed/24638994
http://dx.doi.org/10.1085/jgp.201311038