Molecular Interactions between Mecamylamine Enantiomers and the Transmembrane Domain of the Human α4β2 Nicotinic Receptor

[Image: see text] To characterize the binding sites of mecamylamine enantiomers on the transmembrane domain (TMD) of human (h) (α4)(3)(β2)(2) and (α4)(2)(β2)(3) nicotinic acetylcholine receptors (AChRs), we used nuclear magnetic resonance (NMR), molecular docking, and radioligand binding approaches....

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Detalles Bibliográficos
Autores principales: Bondarenko, Vasyl, Targowska-Duda, Katarzyna M., Jozwiak, Krzysztof, Tang, Pei, Arias, Hugo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971955/
https://www.ncbi.nlm.nih.gov/pubmed/24437521
http://dx.doi.org/10.1021/bi400969x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971955/
https://www.ncbi.nlm.nih.gov/pubmed/24437521
http://dx.doi.org/10.1021/bi400969x

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