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Molecular Interactions between Mecamylamine Enantiomers and the Transmembrane Domain of the Human α4β2 Nicotinic Receptor
[Image: see text] To characterize the binding sites of mecamylamine enantiomers on the transmembrane domain (TMD) of human (h) (α4)(3)(β2)(2) and (α4)(2)(β2)(3) nicotinic acetylcholine receptors (AChRs), we used nuclear magnetic resonance (NMR), molecular docking, and radioligand binding approaches....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971955/ https://www.ncbi.nlm.nih.gov/pubmed/24437521 http://dx.doi.org/10.1021/bi400969x |